| Biography | |
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 Prof. Xing-Cong Li The University of Mississippi, USA |
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| Title: Accelerating Natural Products Drug Discovery with Advanced Chemical and Biological Screening Tools | |
| Abstract: Despite the historical role of natural products as protype drugs or as lead compounds for chemical synthesis of improved drugs, the natural products-based drug discovery has significantly declined over the past two decades due to increased costs for the time-consuming isolation and structure elucidation of the desired active compounds and the re-isolation of already known active compounds, which hinders the discovery effort. To revive this fundamental research discipline, several efforts have been made. In this presentation, the author will introduce an approach involving advanced chemical and biological screening tools to accelerate bioactive natural product discovery. Specifically, natural products extracts will be fractionated into column fractions by high performance liquid chromatography. The resultant fractions will be tested for biological activities. The active fractions will be analysed by ultra-performance liquid chromatography coupled with mass spectrometry and 1H NMR to dereplicate structurally known compounds or identify structurally novel compounds. Examples for identification of antimicrobial and anti-proliferative compounds are given. | |
| Biography: Dr. Xing-Cong Li received B.S. in Medicinal Chemistry from Shanghai Medical University, M.S. in Phytochemistry from Kunming Institute of Botany, Chinese Academy of Sciences, and Ph.D. in Pharmaceutical Science from Hiroshima University, Japan. He is currently a Principal Scientist in the National Center for Natural Products Research at the University of Mississippi, USA. His contributions to science are reflected in more than 150 peer-reviewed publications (h-index 39) in the research areas of antimicrobial natural products discovery, development of natural product dereplication approaches, and determination of absolute configuration of natural products by computational chemistry. Dr. Li served scientific communities as Editor-in-Chief for Research and Reports in Medicinal Chemistry, Associate Editor for Current Organic Chemistry, an editorial board member for seven journals, and a reviewer for NIH Study Section, US Department of Defence Infectious Diseases Panel, and National Natural Science Foundation of China. | |
