| Biography | |
|---|---|
 Prof. Zhen Yuan University of Macau, China |
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| Title: Highly Stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy | |
| Abstract: The development of multifunctional organic nanomaterials is extremely essential for their in vivo cancertheranostic applications. In this study, we report a new BDT-IID based conjugated polymer dots (Pdots) platform that can serve as multifunctional nanoprobes for photoacoustic (PA) imaging-guided photothermal therapy (PTT). The novel BDT-IID Pdots are readily fabricated thoughnanoreprecipitation and can absorb strongly in the near-infrared region (NIR, 650-700 nm). Furthermore, BDT-IID Pdots possess the stable nanostructure and extremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%. More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offer concurrently enhanced PA imaging signals and sufficient photothermal effect. Consequently, the BDT-IID Pdotscan be exploited as a unique theranostic nanoplatform for PA imaging-guided PTT of tumors, holding great promise for their clinical translational development. Keywords：conjugated polymer dots, multifunctional agents, photoacoustic imaging, photothermal therapy | |
| Biography:
Dr. Yuan is an associate professor with the Faculty of Health Sciences at University of Macau (UM). Before joined UM, he had worked as an assistant professor with the Arizona State University and research assistant professor in Biomedical Engineering Dept. with the University of Florida. His academic investigation is focused on cutting-edge research and development in laser, ultrasound and EEG/fMRI-related biomedical technologies as well as their clinical/pre-clinical applications inneuroimaging and neurosciences, and molecular imaging and cancer nanomedicine. He has achieved national and international recognition through more than 150 SCI publications in high ranked journals in his field. He is the editorial board member of Quantitative Imaging in Medicine and Surgery, associate editor of BMC Medical Imaging, andassociate editor of Frontiers in Human Neuroscience. He is a senior member of OSA and senior member of SPIE.
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