m R.N.A. VACCINE production like other biopharmaceutical need various purification stages in the manifacturing  process.

In this process are used technique like : T.F.F., tangential flow filtration  followed by different chromatografic procedure ( affinity and ion exchange separation )  with various kinds of resin an then UF/DF technique. ( ultrafiltration -diafiltration).

So it is of interest to verify the material used for this kind of  procedure as solid phases  or for the membrane and if released impurity in the final product.

 For Silica-based Reversed-Phase packings, a carbon load percentage indicates the amount of functional bonded phase attached to the Silica-base material.

Aim of this work is to investigate the role played by this characteristics in the separation process of  m R.N.A.

Because  this  parameter  influence the  retention time it is interesting to evaluate the use in separation technique of biophramaceutictals.

And this also for the  carbon coated silica colums .

Silica gel for chromatography can be produced by systetic process bu alsto form Rice treated at high temperature .

What kind of effect can be played using an high level of carbon coated silica material on the final purified product ?

The graphitic  particle can be finded as impurity during the manifacturing process of this resins ?

And waht is the role played by carbon  ( graphene- quantum dots) membrane  as reported in various research application?

Applied pharmacologist, hospital pharmacist manager, professorship general toxicology

Professor of environmental toxicology and pharmacology, Previous Europeans specialist laboratory medicine EC4 REGISTERED since 2019.

Many publications and books in scientific discipline : pharmacology , pharmacy , toxicology, pathology , neuroscience, virology , epidemiology, management , ICT

RESEARCH INTEREST  SCORE ON RESEARCHGATE  : MORE THEN 99% OF ALL RG MEMBERS

IMA academy Marijnskaya Italy  Applied chemistry and industrial chemistry branch.