| Biography | |
|---|---|
 Prof. Dong Wang Tianjin University of Science and Technology, China |
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| Title: Design and Synthesis of Complex Pyridine and Partially Saturated Pyridine Derivatives as Putative Drug Candidates | |
| Abstract: Pyridines are pervasive in synthetic chemistry as the most prevalent heteroarenes in pharmaceuticals, and as structural components of many natural products. The majority of synthetic approaches to pyridine derivatives largely rely on the manipulation of prefunctionalized building blocks. However, methods that do not require prefunctionalization can result in more streamlined syntheses and can enable the late stage diversification of complex molecules. Completely different from the conventional methods, we have developed synthetic methods that will enable the direct functionalization of pyridines through substrate design and mechanism study. Utilizing cheap and easily accessible pyridine N-oxides as substrates, the facile and efficient synthesis of those complex bioactive pyridine derivatives, including azacoumarins, azachromones, azabenzofurans, azaindoles, et al. has been established under appropriate activation conditions. In addition, the selective saturation and functionalization of heteroaromatics remains problematic. We have developed synthetic methods that could convert pyridine and quinoline derivatives to various partially saturated pyridine derivatives, including dihydropyridines, dihydroquinolines, tetrahydropyridines and tetrahydroquinolines. The synthetic methods are all performed in a one-pot operation under transition-metal- and reductant-free conditions. These findings will not only provide highly efficient and concise synthetic methods for complex pyridine and partially saturated pyridine derivatives, but also provide new ideas for the functionalization of nitrogen heteroaromatics. | |
| Biography: Dong Wang is currently an associate Professor at Tianjin University of Science and Technology. He received his Ph.D. in Chemistry from Louisiana State University (USA, 2011) under the guidance of Prof. William E. Crowe. After his Ph.D., he joined the Longwood Biopharmaceuticals company working on the design and synthesis of hepatitis C virus NS3 polymerase inhibitors. His research is focused primarily upon the development of new strategies and methodologies for the synthesis of nitrogen heterocycles, including complex pyridine and quinoline derivatives, dihydropyridine and dihydroquinoline derivatives, tetrahydropyridine and tetrahydroquinoline derivatives, et al. His research group has successfully established mild and efficient methods for a series of biologically active nitrogen heterocycles, such as azacoumarins azachromones, azabenzofurans, azaindoles, et al. As the first or corresponding author, He has 20 publications in this area so far. | |
