Organometallic compounds are widely used coupling reagents, but their limitations, such as sensitivity to air and water, have hindered their further application in highly functionalized complex substrate synthesis. Therefore, the development of new water-resistant and oxygen-resistant organometallic coupling reagents is of great significance. Our research group utilized water-resistant and oxygen-resistant organoantimony chloride as a raw material and synthesized a series of arylstibines, alkynlstibines, alkylstibines, and stibines sulfide compounds through nickel, copper, zinc, and other inexpensive transition metal catalyzed or mediated methods. These synthesized organoantimony compounds were used as coupling reagents, effectively solving the problem of highly selective and efficient synthesis of biphenyl compounds, biphenyl methane derivatives, and diene and triene compounds with similar functional groups and polarities.^[1-5]

References

[1]. Zhang, D.; Le, L.; Qiu, R., et al. Angew. Chem. Int. Ed., 2021, 60, 3104-3114.

[2]. Le, L.; Li, S.; Qiu, R., et al. Org. Lett., 2022, 24, 6159-6164.

[3]. Zhang, D.; Tang, T.; Qiu, R., et al. ACS Catal., 2022, 12, 854-867.

[4]. Zhang, D.; Xu, Z.; Qiu, R., et al. Org. Lett., 2022, 24, 3155-3160.

[5]. Zhang, Z.; Zhang, D.; Qiu, R., et al. Org. Lett., 2021, 23, 5317-5322.

Qiu Renhua, male, born in 1981, is a professor at the College of Chemistry and Chemical Engineering, Hunan University. His research interests include organic antimony chemistry and saturated carbon chemistry. He has published more than 120 academic papers in journals such as Angew. Chem. Int. Ed., ACS Catal., Org. Lett., and J. Org. Chem., and has been granted more than 40 invention patents.