| Biography | |
|---|---|
 Dr. Devalina Ray Amity University, Noida, India |
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| Title: Transition metal-catalyzed site-selective C-H functionalization of N-heteroaromatics | |
| Abstract: Nitrogen containing heterocycles and their analogues are ubiquitous organic scaffolds found in nature and are known as medicinally important pharmacophores, among which azoles, pyrroles, indoles and quinolines have the most frequent occurrence. Hence, the synthetic exploration and expansion of their applications is critical for realizing their full potential. The inherent reactivity of these heteroarenes has enabled direct bond formation even in unfunctionalized scaffolds through transition-metal catalysis. In this context, the Cu-catalyzed site selective C2-H activation followed by intramolecular cross dehydrogenative coupling (CDC) of 3-substituted pyrroles and indole derivatives was established for direct access to polycyclic heteroarenes in moderate to good yields. Interestingly, the Pd-catalyzed reaction conditions for 3-substituted pyrrole derivatives preferred C5-selective intramolecular CDC over C2-selective products (Scheme 1). Further, as an advancement towards regioselective C-H functionalization of N-heteroaromatics, transition-metal free intermolecular C5-H chalcogenation of 8-aminoquinolines was developed under mild reaction conditions. The successful implementation of this methodology was further established through late stage derivatization of pamaquine analogue which is known to be an efficient antimalarial.
References: 1.Kumar, V.; Banert, K.; Ray, D.; Saha, B; Org. Biomol. Chem. 2019, 17, 10245-10250. 2.Ray, J. K.; Singha, R.; Ray, D.; Ray, P.; Yogeswara Rao, D.; Anoop, A. Tetrahedron Letters 2019, 60, 931-935 3.Tripathy, K. N.; Ray, D.; Singh, R. P. Org. Biomol. Chem. 2017, 15, 10082-10086. 4.Tripathy, K. N.; Ray, D.; Singh, R. P. Eur. J. Org. Chem. 2017, 5809-5813. 5. Ray, D.; Manikandan, T.; Roy, A.; Tripathy, K.N.; Singh, R. P. Chemical Communications 2015, 51, 7065-7068. | |
| Biography: Dr. Devalina Ray has an overall teaching and research experience of 10 years. She received her Ph.D. in synthetic organic chemistry from the Indian Institute of Technology Kharagpur, India in 2008. Her postdoctoral research experience abroad spanned from 2008- 2012 in the University of Texas Medical Branch, Texas and University of Nebraska Medical Centre, Nebraska in USA, Myongji University and Hanyang University, South Korea. Thereafter, she received Young Scientist fellowship from Govt. of India to pursue her research in the Department of Chemistry, Indian Institute of Technology- Delhi, India from 2014-2017. She started her independent academic career as Assistant Professor in Department of Biotechnology, Amity University, Noida, India in 2017. Her research interest comprises of transition-metal-catalyzed C–H activation and 1,3-dipolar addition, transition metal free C-H functionalization of N-heteroaromatics and synthesis of small molecule peptide inhibitors for protein-protein interactions related to cancer. She had received two research grants as sole PI from Govt of India in last 5 years. Her research achievements are reflected through 16 international publications in reputed journals along with one granted patent. | |
