Biography
Prof. Myongsoo Lee
Prof. Myongsoo Lee
Jilin University, China
Title: Supramolecular Assembly with Mechanical Motions
Abstract: 

In this symposium, I will introduce our recent results how to construct dynamic self-assembled nanostructures exhibiting switchable functions, inspired by life systems. For example, synthetic tubular pores are able to undergo open-closed switching driven by an external signal, which function as an artificial enzyme. When self-assembled tubules embed DNA inside the hollow cavities, the DNA-coat assembly undergoes collective motion in helicity switching. In the case of toroid assembly, the static toroids are able to undergo spontaneous helical growth when they switch into out-of-equilibrium state. The helical growing drives shaping of spherical vesicles into tubular vesicles, reminiscent of microtubles. Moving from 1-D to 2-D structures, the internal pores are able to form chiral interior which selectively capture only one enantiomer in racemic solution with perfect pore performance. I will discuss recently discovered these results with their biological implications.

References

[1] B. Sun, Y. Kim, Y. Wang, H. Wang, X. Liu, M. Lee, Nature Mater. 2018, 17, 599.

[2] Y. Kim, H. Li, X. Chen, X. Ma, M. Lee, Nature Nanotech. 2017, 12, 551

[3] X. Chen, Y. He, Y. Kim, M. Lee, J. Am. Chem. Soc. 2016, 138, 5773.

[4] B. Shen, Y, He, Y. Kim, Y. Wang, M. Lee, Angew. Chem. Int. Ed. 2016, 55, 2382

[5] Y. Kim, J. Kang, B. Shen, Y. Wang, Y. He, M. Lee, Nature Commun. 2015, 6, 8650.

[6] Z. Huang, S.-K. Kang, M. Banno, C. Seok, E. Yashima, M. Lee, Science 2012, 337, 1521

Biography: 
Prof. Lee received his Ph.D. degree in Macromolecular Science from Case Western Reserve University in 1993. After postdoctoral appointments at University of Illinois at Urbana-Champaign, he joined the Faculty of Chemistry at Yonsei University (1994), Seoul National University (2009), and then moved to Jilin University in 2013, where he is presently Distinguished Professor. His main research interests include intelligent supramolecular systems, dynamic self-assembly with mechanical motion, and bioactive peptide and carbohydrate nanostructures. Prof. Lee has authored and co-authored over 210 papers. Most of his works have been published in the highly-reputed journals such as Science (2012), Nature Mater. (2005, 2018), Nature Nanotech. (2017), Nature Commun. (2011, 2016), Angewandte Chemie, and JACS.